In this BJ Disease paper, which is freely available to all readers, Bart Vanhaesebroeck and colleagues present results which show that inactivation of either p110α or p110β of PI3K (phosphoinositide 3-kinase) can counteract the impact of inactivation of the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10).

In this BJ Signal paper, which is freely available to all readers, Christopher Proud and colleagues provide the first insights into the allosteric control of eEF2K (eukaryotic elongation factor 2 kinase), and propose a model for the functional organization and control of eEF2K.

In this BJ Metabolism paper, Peter Shepherd and colleagues have investigated the effects of a range of inhibitors with varying specificity for class-I PI3K (phosphoinositide 3-kinase) isoforms and mTOR (mammalian target of rapamycin) on whole-body glucose metabolism in mice, and provide pharmacological evidence to support a pre-eminent role for the p110α isoform of PI3K in pathways that acutely regulate glucose metabolism.