In this paper, Muria Barbarroja and colleagues have explored whether differences in inflammatory and insulin signalling pathways in visceral adipose tissue might account for the metabolic differences exhibited by morbidly obese individuals who are either insulin-resistant or, paradoxically, insulin-sensitive.
In this paper, by screening a combinatorial library Max Chang, Michael Giffin, Bruce Torbett and others have discovered an allosteric, non-competitive inhibitor of HIV protease which may be more efficacious at inhibiting viral replication and countering the emergence of drug resistance.
A paper by Professor Laura Machesky and colleagues (CRUK Beatson Institute for Cancer Research, Glasgow) has shed light on how genetic damage to muscle proteins can lead to the development of the rare muscle wasting disease, nemaline myopathy. A press release on this paper is available
here.
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